LMCE2023

[EW01]
Dxome Co., Ltd.

Copy number variation (CNV) is not easily detectable with conventional Sanger sequencing, so CNVs have been underestimated in clinical genetics. Meanwhile, with the advent of next-generation sequencing (NGS), the detection of CNV has become technically possible and it is expected that more and more CNV could be detected. However, even after several years’ clinical NGS experience in Korea, the attitude toward CNV has not changed dramatically.
The talks in this session will cover the theoretical background and current update of CNV detection methods including Copy-number Analysis by BAse-level NormAlization (CABANA) developed by Dxome (Korea) in collaboration with our group, and a Korean clinical laboratory’s CNV detection experience will be shared among the audience.

[EW02]
BIONEER Corp.

After emerging from the global impact of COVID-19, a heightened awareness of syndromic diagnostic tests has taken hold. There is a growing demand for a system capable of efficiently testing patient samples in a rapid manner. In order to fulfill this demand, we have innovated an all-in-one syndromic diagnostic kit, using Real-Time PCR technology. This cutting-edge kit can perform multiplex detection accommodating a range from a minimum of 6 samples up to a maximum of 94 samples per run.
In attempt to assess the analytical performance of different test kits, we employed the ExiStationTM FA 96/384 system. This automated platform seamlessly manages from the de-capping of primary sample tubes to nucleic acid extraction, finishing with PCR analysis. Consequently, users remain safeguarded from exposure to pathogens as every step from de-capping to sample dispensing and re-capping occurs within the ExiStationTM FA 384 which is equipped with a HEPA filter.
We take pride in presenting our PCR test kits currently in development, planned for future release.

[EW03]
SD Biosensor, Inc.

Clostridioides difficile is a leading cause of healthcare-associated diarrhea and is a known cause of antibiotic-associated diarrhea and pseudomembranous colitis.
Laboratory tests and endoscopy have been used to diagnose C. difficile infection (CDI). Among the laboratory tests, the gold standard is the cell cytotoxicity assay and toxigenic C. difficile culture, which are difficult to use in hospital laboratories. Recently, a multi-step algorithm using a glutamate dehydrogenase assay, a nucleic acid amplification technique, and toxin A/B assay have been widely used clinically.
This presentation will discuss strategies for better CDI diagnosis based on laboratory methods and recently recommended algorithms.

[EW04]
Abbott Korea

Cardiovascular disease is one of the most important causes of death worldwide. The number of people hospitalized due to cardiovascular disease is rapidly increasing by about 4 times from 2002 to 2018 in Korea. Cardiac biomarkers not only have played an essential role in the diagnosis of myocardial disease, but also they can be used for the purpose of risk stratification of cardiovascular disease in asymptomatic patients. Recently international guidelines show expanded indications of cardiac biomarkers for non-cardiac surgery and diabetic patients.

[EW05]
Siemens Healthineers Ltd.

The lab is at the heart of delivering high quality patient experiences, where speed and accuracy are essential in building trust and confidence. When high-quality diagnostics are delivered closer to home, communities have the potential to grow healthier.
Powered by sophisticated AI and intuitive User Interface, the Atellica CI 1900 Analyzer enables every modern lab, in every setting, to overcome challenges and make a meaningful impact in the communities you serve.
Atellica CI 1900 analyzer delivers comprehensive assay menu standardized to the Atellica Solution portfolio, enables continuous operations through integrated chemistry and immunoassay testing in the smallest footprint available.

[EW06]
Seegene Inc.

M. genitalium, a major sexually transmitted pathogen, remains poorly understood in various aspects of its significance. It is a major cause of male urethritis, and its presence increases the risk of acquiring other infections. For females, untreated M. genitalium infections can lead to pelvic inflammatory disease(PID) and increase the risk of premature birth in pregnant women. In this session, we will explore the current domestic infection status of M. genitalium and shed light on emerging issues related to treatment and control, particularly focusing on the escalating problem of antimicrobial resistance.

[EW07]
Seegene Medical Foundation

[EW08]
BD Korea

Today, AMR is one of the world’s greatest health threats, causing over 1 million deaths each year, and that number is growing. If left unabated, the effects of AMR could be worse than COVID-19. Future projections suggest that AMR could result in millions of deaths and trillions of dollars in lost global production.
BD is committed to combatting antimicrobial resistant (AMR).
Through this session, BD will provide the latest information on the treatment and diagnosis of multi-drug resistant GNB.

[EW09]
Mindray Medical Korea Ltd. Co.

The BC-700 series integrates an automatic ESR module in a hematology analyzer. It can also generate both CBC & ESR results in one test within 1.5 min. In addition, it saves the costs that would otherwise be incurred for the purchase, maintenance, consumables, and storage space of a separate ESR analyzer. Compared with the traditional Westergren method, this method performs better in quality traceability, repeatability, speed, safety, and level of automation.

[EW10]
Sebia

Therapeutic monoclonal antibody (mAb) inclusion in Multiple Myeloma treatment regimens offer patients significant improvements in clinical outcomes. daratumumab is human mAb targeting CD38 used in Multiple Myeloma treatment regimens. Immunotherapies for Multiple Myeloma, like the monoclonal antibody daratumumab, can create false positive IgG Kappa bands on Immunofixation gels. This workshop describes best practice for using the Hydrashift assay to remove daratumumab interference from Immunofixation gels.

[EW11]
Thermo Fisher Scientific Korea

Post-natal CMA test reimbursement started preliminary reimbursement since August 2019. This passed conformity assessment this June and it will be changed to regular reimbursement item.
We consider what this change means and what impact it may have on patients and their families in the future.

[EW12]
GC Labs

This session will introduce the GC Labs ESAC (Endocrine Substance Analysis Center) and EDC (Endocrine Disrupting Chemicals) analysed in GC Labs ESAC.
GC Labs, the top tier referral laboratory in Korea, will greatly contribute to improving our national health, not only by accurately measuring the EDC accumulated in the human body, but also by studying the clinical significance and impact of various EDC on human health and disease.

[EW13]
Invitros

This session focuses on in vitro tests for serum allergen-specific IgE such as the Multiple Allergen Simultaneous Test (MAST) and ImmunoCAP. It aims to provide an understanding of the concept of allergy and allergic diseases, as well as explain how allergen-specific IgE screening tests are utilized in clinical practice with their interpretations and limitations.

[EW14]
Sysmex Korea

Cancer patients receive a variety of treatments, including anticancer drugs and antibiotics, during chemotherapy, and their immune system often changes due to diabetes, high blood pressure, and other systemic diseases.
Because there is no tool to measure it, the impact of the patient's immune status on existing treatment, the patient's survival time remains uncertain. The number of white blood cells, red blood cells, platelets, etc. only reflects the degree of vulnerability to infection or bleeding and cannot be used as a prediction or prognostic factors for the treatment. Additionally, various inflammatory cells, including T lymphocytes, can only be tested at the laboratory level, so it has limitations to implement to routine clinical practice.
So, we are trying to develop an indicator that can simply analyze the patient's immune status and evaluate its usefulness by using various parameters of the XN instrument, Sysmex's Hematology Analyzer.

[EW15]
Roche Diagnostics Korea

Accurate quantification of Epstein-Barr Virus (EBV) and BK Virus (BKV) is crucial for patients undergoing transplantation, as these viruses can cause significant post-transplant complications. The Roche cobas EBV and BKV provide a reliable tool for detecting and monitoring these viruses. In this session, I will present an experience in evaluating the performance of cobas EBV and BK virus systems using WHO standard material. The cobas system shows good analytical performance for EBV and BK virus quantification.

[EW16]
Beckman Coulter Korea Ltd.

The biomarkers have been used routinely in many areas in medicine for accurate diagnosis, management, prognosis and risk stratification. Cardiac biomarkers are essential for the definition of acute myocardial infarction and heart failure and are also a powerful tool for triaging.
The introduction of a high-sensitivity troponin assay has been useful in patients with non-STEMI, which allows diagnosis by a single measurement and a serial measurement. “High-sensitivity” refers to analytical, which detect troponin precisely in a very low concentration.
BNP and NT-proBNP are widely used to help in distinguishing patients with cardiac dyspnea from with non-cardiac disease. The incorporation of BNP and NT-proBNP into routine clinical care is the first step into the realm of biomarker-supported evaluation and management of patients with heart failure. In this session, the current application of troponin and BNP/NT-proBNP will be reviewed.

[EW17]
SS Medipia

Maintaining proper hemostasis is crucial for women's health, as it ensures adequate control of bleeding during menstruation, pregnancy, and childbirth. Hemostasis ensures that menstruation process occurs without excessive bleeding and prevents excessive bleeding during delivery while minimizing the risk of thrombotic events. Hemostatic mechanisms, including uterine contraction and clot formation, play a crucial role in preventing and managing postpartum bleeding. Women with Von Willebrand disease (VWD) may experience heavy menstrual bleeding, bleeding during childbirth, and prolonged bleeding after surgeries or dental procedures. Inherited and acquired thrombophilias, such as factor V Leiden mutation or antiphospholipid syndrome (APS), pose risks during pregnancy.